Fresh off their bye, the 4-2 Bills head to Charlotte to face the 4-3 Carolina Panthers. Buffalo is looking to avoid their 3rd straight loss while the Panthers are seeking their 4th straight win. Andy Dalton gets the start for an injured Bryce Young, and the Bills have three players making their 2025 debuts.

The Bills played their most entertaining game of the preseason Saturday in their final game before roster cutdowns with a 31-26 loss to the Carolina Panthers. All of the expected starters heading into the regular season sat to prevent any more injuries to an already banged-up roster. Some positives came out of this game, but the challenge is how many will translate to the regular season since most players will not be on the 53-man roster after 4 p.m. on Tuesday.