When and Where: Sunday, October 5th, 8:20 PM at Highmark Stadium
How to Watch: Airing on NBC
Betting Line: Buffalo -7.5 O/U 49.5

The Buffalo Bills host the New Orleans Saints for their first matchup in Orchard Park since 2017. First-year Head Coach Kellen Moore will be looking for a statement win early in his coaching career.

The Buffalo Bills welcome the Miami Dolphins to Orchard Park for a Thursday Night Football matchup between the division rivals. Tua Tagovailoa is 0-5 at Highmark Stadium, and 1-7 vs the Bills in his career as a starter.

The Bills head to New Jersey to face off with their division rival, Jets, led by first year Head Coach Aaron Glenn and Quarterback Justin Fields.

Buffalo kicks off their final season in Highmark Stadium on Sunday Night Football. The Bills welcome Lamar Jackson and the Baltimore Ravens to Orchard Park in a matchup between the reigning NFL MVP, Josh Allen, and the 2023 NFL MVP, Lamar Jackson.

Season finale on HBO MAX of Hard Knocks: Training Camp With The Buffalo Bills

The 2025 NFL 53-man roster deadline is Tuesday, August 26, at 4 PM. All 32 teams must cut their training camp rosters down from the 90-player max to the initial 53-player active roster before the regular season begins. Expect a few trades and some surprises around the league. Who will be a surprise cut or trade from the Bills? DeWayne Carter and Curtis Samuel’s names have been floating around as trade candidates. Will DaQuan Jones and Mitch Trubisky be cap casualties?

The Bills head to Tampa Bay for their preseason finale against the Buccaneers in a scheduling rarity of facing a team in the preseason that they will also play in Week 11 at Highmark Stadium.

The Buffalo Bills head to Chicago for their second preseason game against first year Head Coach Ben Johnson and the Bears. This marks the third straight preseason matchup between the two teams.

The Bills kick off the preseason with their only home appearance against the New York Giants. This is also Bills’ Kids Day with a Junior Tailgate starting at 9 AM sponsored by Fisher-Price.

Day 10, 2025 Training Camp, at St. John Fisher University in Rochester, NY.

Open to the Public

Day 9, 2025 Training Camp, at St. John Fisher University in Rochester, NY.

Open to the Public

Season premiere on HBO MAX of Hard Knocks: Training Camp With The Buffalo Bills

Day 8, 2025 Training Camp, at St. John Fisher University in Rochester, NY.

Open to the Public

The Buffalo Bills will host their annual Return of the Blue and Red practice at Highmark Stadium.

Open to the Public

Day 7, 2025 Training Camp, at St. John Fisher University in Rochester, NY.

Open to the Public

Day 6, 2025 Training Camp, at St. John Fisher University in Rochester, NY.

Open to the Public

Day 5, 2025 Training Camp, at St. John Fisher University in Rochester, NY.

Open to the Public

Day 4, 2025 Training Camp, at St. John Fisher University in Rochester, NY.

Open to the Public

Day 3, 2025 Training Camp, at St. John Fisher University in Rochester, NY.

Open to the Public

Day 2, 2025 Training Camp, at St. John Fisher University in Rochester, NY.

Open to the Public

The Buffalo Bills kick off their 2025 Training Camp at St. John Fisher University in Rochester, NY.

Open to the Public

Teams are allowed to conduct a total of 10 days of organized team practice activity or “OTAs.” No live contact is permitted, but 7-on-7, and 11-on-11 type drills are permitted. This is the final scheduled OTA workout session for the Bills before their mandatory minicamp.