Buffalo's full schedule and ticket information will be exclusively revealed on the team's official channels on May 14 at 7:30 p.m. via the team website, X, Instagram, and Facebook. The Bills play eight home games and nine opponents on the road. Aside from AFC East division games, the Bills play the AFC West, NFC North, and face the second-place teams in the AFC North, AFC South, and NFC West.

The full 2026 NFL regular-season schedule will be officially released at 8 PM. All 272 games across 18 weeks, including prime-time matchups, the Thanksgiving and Christmas slates, and the full international series.