The 7-3 Buffalo Bills travel to face the 5-5 Houston Texans on Thursday Night Football in a pivotal AFC showdown. Buffalo looks to earn a second straight win and keep pace in the AFC playoff race, while Houston aims to climb back above .500 and strengthen its postseason hopes.

The 6-3 Buffalo Bills host the 6-3 Tampa Bay Buccaneers in a pivotal Week 11 matchup at Highmark Stadium. Both teams look to rebound from last week’s losses and keep pace in the AFC and NFC playoff picture.

The 5-2 Buffalo Bills host the 5-3 Kansas City Chiefs in a marquee Week 9 matchup this Sunday at Highmark Stadium. Both teams enter the game looking to make a statement in the AFC race — with playoff implications already starting to take shape.

Fresh off their bye, the 4-2 Bills head to Charlotte to face the 4-3 Carolina Panthers. Buffalo is looking to avoid their 3rd straight loss while the Panthers are seeking their 4th straight win. Andy Dalton gets the start for an injured Bryce Young, and the Bills have three players making their 2025 debuts.

Coming off their first loss of the season, the 4-1 Bills head to Atlanta to face the 2-2 Falcons fresh off their bye week. Buffalo looks to return to their winning ways and maintain their position at the top of the AFC East and keep pace with the Indianapolis Colts in the battle for the AFC’s one seed.

The 4-0 Bills are seeking their 15th straight victory at home against the 2-2 Patriots in a battle between the AFC East’s best teams on Sunday Night Football. Buffalo has started the season with four straight 30+ point performances and looks to continue their homefield dominance before hitting the road for the rest of October.

The 3-0 Bills are seeking their 14th straight victory at home against the 0-3 Saints in their last home 1:00 PM game until November. Buffalo has started the season with three straight 30+ point performances for the second year in a row and look to continue their home field dominance against first year head coach Kellen Moore.

The 2-0 Buffalo Bills return to Orchard Park for a Thursday Night Football matchup with their division rival, the Miami Dolphins. Miami is looking to bounce back from its disastrous start to the season and avoid a 0-3 hole. The Bills are looking to win their seventh straight matchup over the Fins.

The Buffalo Bills fresh off their Sunday Night Football comeback over the Ravens travel to New Jersey for an AFC East battle with the 0-1 New York Jets. Can Josh Allen keep his hot streak going and make it four consecutive victories versus the division rival?

The Buffalo Bills kick off the 2025 regular season and Highmark Stadiums’ Farewell Season, with a Sunday Night Football clash with the Baltimore Ravens. This preview will cover the key storylines, injury news, matchups to watch, x-factors, and my keys to victory and prediction.

The Buffalo Bills face the number one seed and back-to-back defending Super Bowl Champion Kansas City Chiefs at Arrowhead Stadium at 6:30 PM this Sunday on CBS. This will be the fourth matchup in the playoffs between the two teams over the last five seasons. Buffalo lost to the Chiefs in the 2020 AFC Championship and the 2021 and 2023 Divisional Rounds.

The Buffalo Bills welcome the Baltimore Ravens to Western New York this weekend in a highly anticipated Divisional Round matchup between the AFC’s two and three seeds. The Bills defeated the Broncos 31-7 in the Wild Card round while the Ravens knocked off their division rival Pittsburgh Steelers, 28-14. A lot has changed since their regular season meeting in Week Four, where the Ravens won handily, 35-10.

The Buffalo Bills welcome the Denver Broncos to Western New York this weekend in a Wild Card matchup between the AFC’s two and seven seeds. The Bills secured their playoff spot over a month ago when they locked up the AFC East. The Broncos clinched theirs in Week 18 against the Kansas City Chiefs’ backups.

The 13-3 Buffalo Bills head to Foxboro for their last game of the regular season against the 3-13 New England Patriots. The Bills narrowly defeated New England two weeks ago, 24-21. This matchup will look a bit different as the Bills are planning to rest starters, with Josh Allen starting to continue his NFL-leading starts streak.

The 12-3 Buffalo Bills welcome the 4-11 Jets to New York for their second matchup of the season. Both teams have gone down different paths since their week six meeting, with the Bills going 8-1 since then and the Jets going 2-7. A victory on Sunday would secure the two seed and cap off Buffalo’s first undefeated record at home since the 1990 season.

The Buffalo Bills return home after their victory over the Detroit Lions to face the 3-11 New England Patriots. This is the first of two matchups over the final three weeks of the season for the AFC East rivals. With the two teams heading in different directions, Buffalo needs to keep its focus and continue its solid play for the remainder of the season. New England wants something positive to end a disappointing season under first-year head coach Jerod Mayo.

The Bills head to Detroit for a highly anticipated matchup between two of the best teams in the NFL. Buffalo is looking to rebound from their worst defensive performance since the 2021 season after their 44-42 loss to the Rams in Week 14. The Lions are on an 11-game winning streak and have overcome a rash of injuries while maintaining a one-game lead in the competitive NFC North.

The Buffalo Bills defeated the San Francisco 49ers 35-10 on a snowy Sunday night to clinch their fifth straight AFC East crown. Buffalo is the first team to clinch a division this season and the earliest (5 weeks remaining) to do so since the 2009 Indianapolis Colts. With the Bills’ seventh consecutive win and sixth straight game at 30+ points, Sean McDermott is now 8-0 coming off a bye week in his career.

The Bills are fresh off the bye week and welcome the reigning NFC Champion San Francisco 49ers to Highmark Stadium for Sunday Night Football. Buffalo is 7-0 off the bye since Sean McDermott became the head coach and is facing a desperate 49ers team that has lost its last two games. Brock Purdy returns to the lineup but San Francisco will be missing some key players on both sides of the ball. The Buffalo will be without Dalton Kincaid but All-Pro LB Matt Milano is expected to make his return to the field.

Bills vs. Chiefs week is here. Like many others, I have had this game circled since the schedule was released earlier this year. Josh Allen and Patrick Mahomes are the two best quarterbacks in the NFL, and their matchups have proven to be must-see TV. If the Bills have any hope of obtaining the number one seed in the AFC come playoff time, this is a game they need to win.